Beilstein J. Org. Chem.2014,10, 2580–2585, doi:10.3762/bjoc.10.270
very strong inhibitor, with a Ki value of 32.5 pM. It was also shown that the furan analogue of thiamine can be functionalised at the C-2 position, which will allow access to mimics of reaction intermediates of various ThDP-dependent enzymes.
Keywords: furan synthesis; gold-catalysedcyclisation
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Graphical Abstract
Figure 1:
Structure of thiamine diphosphate (ThDP, 1).